与安慰剂相比，克仑特罗和特布他林对心脏、肺部及神经肌肉的影响。
Cardiac, pulmonary and neuromuscular effects of clenbuterol and terbutaline compared with placebo.
作者信息
Whitsett T L, Manion C V, Wilson M F
出版信息
Br J Clin Pharmacol. 1981 Aug;12(2):195-200. doi: 10.1111/j.1365-2125.1981.tb01200.x.
Abstract
1 Cardiac, neuromuscular (tremor) and pulmonary effects of multiple single oral doses of clenbuterol (40, 60 and 80 micrograms) and terbutaline (2.5 and 5 mg) were compared with placebo in thirteen patients with reversible obstructive airways disease. 2 The percent change in the bronchodilator and neuromuscular effects of clenbuterol and terbutaline were greater than that of the cardiac activity. 3 Both drugs decreased T wave amplitude and occasionally caused J point ST segment depression. These changes were considered typical of this class of drugs and clinically insignificant. 4 While these drugs had comparable cardiac, pulmonary and neuromuscular effects, clenbuterol, at larger doses, had a higher incidence of transient headaches and nervousness.
摘要
- 在13例可逆性阻塞性气道疾病患者中，比较了多次单次口服不同剂量克仑特罗（40、60和80微克）和特布他林（2.5和5毫克）与安慰剂对心脏、神经肌肉（震颤）和肺部的影响。2. 克仑特罗和特布他林的支气管扩张和神经肌肉效应的变化百分比大于心脏活动的变化百分比。3. 两种药物均降低T波振幅，偶尔引起J点ST段压低。这些变化被认为是这类药物的典型表现，临床上无显著意义。4. 虽然这些药物在心脏、肺部和神经肌肉方面有相似的作用，但大剂量的克仑特罗出现短暂头痛和紧张的发生率更高。
相似文献
1
Cardiac, pulmonary and neuromuscular effects of clenbuterol and terbutaline compared with placebo.与安慰剂相比，克仑特罗和特布他林对心脏、肺部及神经肌肉的影响。
Br J Clin Pharmacol. 1981 Aug;12(2):195-200. doi: 10.1111/j.1365-2125.1981.tb01200.x.
2
Oral NAB 365 (clenbuterol) and terbutaline in chronic obstructive lung disease: a double-blind, two-week study.口服NAB 365（克仑特罗）和特布他林治疗慢性阻塞性肺疾病：一项双盲、为期两周的研究。
Int J Clin Pharmacol Ther Toxicol. 1980 Jan;18(1):21-5.
3
A clinical trial of oral clenbuterol (NAB 365) in chronic airways obstruction.
Curr Med Res Opin. 1980;6(7):449-55. doi: 10.1185/03007998009109466.
4
Intravenous NAB 365 (clenbuterol) and terbutaline in exercise-induced bronchospasm (EIB).静脉注射NAB 365（克仑特罗）和特布他林治疗运动诱发性支气管痉挛（EIB）。
Clin Allergy. 1979 May;9(3):277-82. doi: 10.1111/j.1365-2222.1979.tb01554.x.
5
Oral clenbuterol and procaterol. A double-blind comparison of bronchodilator effects in children with chronic asthma.
J Asthma. 1987;24(6):347-53. doi: 10.3109/02770908709070966.
6
7
[Novel quantitative assessment of the tremorogenic effects of the beta 2-mimetics clenbuterol and salbutamol after oral administration].
Arzneimittelforschung. 1985;35(8):1299-302.
8
[Placebo-controlled comparative study of clenbuterol and terbutaline in asthmatic children].
Rev Alerg Mex (1987). 1989 Mar-Apr;36(2):61-4.
9
Clenbuterol and salbutamol in the symptomatic treatment of patients with reversible airways obstruction.
Pharmatherapeutica. 1983;3(7):492-5.
10
A 3-month comparison of formoterol with terbutaline via turbuhaler. A placebo-controlled study.福莫特罗与特布他林通过都保吸入器给药的3个月对比研究。一项安慰剂对照试验。
Ann Allergy Asthma Immunol. 1998 Sep;81(3):225-30. doi: 10.1016/S1081-1206(10)62816-5.
引用本文的文献
1
Detection of Clenbuterol-Induced Changes in Heart Rate Using At-Home Recorded Smartwatch Data: Randomized Controlled Trial.利用家用智能手表记录数据检测克伦特罗引起的心率变化：随机对照试验
JMIR Form Res. 2021 Dec 30;5(12):e31890. doi: 10.2196/31890.
2
Effects of Terbutaline Sulfate on Physiological and Biomechanical as Well as Perceived Exertion in Healthy Active Athletes: A Pilot Study.硫酸特布他林对健康活跃运动员生理、生物力学及主观用力感觉的影响：一项初步研究。
J Hum Kinet. 2019 Oct 18;69:169-178. doi: 10.2478/hukin-2018-0097. eCollection 2019 Oct.
3
Acute supra-therapeutic oral terbutaline administration has no ergogenic effect in non-asthmatic athletes.急性超治疗剂量口服特布他林给药对非哮喘运动员没有运动表现增强作用。
Eur J Appl Physiol. 2013 Feb;113(2):411-8. doi: 10.1007/s00421-012-2447-0. Epub 2012 Jul 6.
4
A comparative study of a new selective beta 2-adrenoceptor agonist, procaterol and salbutamol in asthma.新型选择性β2肾上腺素能受体激动剂丙卡特罗与沙丁胺醇治疗哮喘的对比研究
Br J Clin Pharmacol. 1985 Jun;19(6):787-91. doi: 10.1111/j.1365-2125.1985.tb02715.x.
5
Dose-response study with high-dose inhaled salmeterol in healthy subjects.健康受试者高剂量吸入沙美特罗的剂量反应研究。
Br J Clin Pharmacol. 1992 Mar;33(3):342-5. doi: 10.1111/j.1365-2125.1992.tb04049.x.
本文引用的文献
1
Electrocardiographic effects of arterenol and isopropylarterenol in man, with a note on the auricular T wave.去甲肾上腺素和异丙肾上腺素对人体的心电图影响，并论及心房T波
J Appl Physiol. 1950 Nov;3(5):235-42. doi: 10.1152/jappl.1950.3.5.235.
2
The normal Q-T interval.正常Q-T间期。
Am Heart J. 1962 Jun;63:747-53. doi: 10.1016/0002-8703(62)90059-5.
3
Applicability of correcting the QT interval for heart rate.
Am Heart J. 1980 May;99(5):678. doi: 10.1016/0002-8703(80)90746-2.
4
The bronchodilator and cardiac effects of five pressure-packed aerosols in asthma.五种压力包装气雾剂对哮喘的支气管扩张和心脏效应
Br J Dis Chest. 1970 Jan;64(1):37-45. doi: 10.1016/s0007-0971(70)80047-x.
5
Effects of adrenergic receptor activation and blockade on the systolic preejection period, heart rate, and arterial pressure in man.肾上腺素能受体激活与阻断对人体收缩期射血前期、心率及动脉压的影响。
J Clin Invest. 1967 Nov;46(11):1704-14. doi: 10.1172/JCI105661.
6
Beta-adrenergic mechanisms in action tremor.动作性震颤中的β-肾上腺素能机制
N Engl J Med. 1975 Nov 6;293(19):950-3. doi: 10.1056/NEJM197511062931902.
7
Dose-response study of a new oral bronchodilator, NAB 365 (clenbuterol).
Int J Clin Pharmacol Biopharm. 1978 Dec;16(12):589-93.
8
Study of a new oral beta-adrenergic drug, clenbuterol, in patients with chronic bronchitis.新型口服β-肾上腺素能药物克仑特罗治疗慢性支气管炎患者的研究。
Eur J Clin Pharmacol. 1978 May 31;13(3):171-7. doi: 10.1007/BF00609979.
9
A trial of clenbuterol in bronchial asthma.克仑特罗治疗支气管哮喘的试验。
Thorax. 1977 Dec;32(6):717-9. doi: 10.1136/thx.32.6.717.
10
The bronchodilator effect of NAB 365.
Br J Clin Pharmacol. 1977 Feb;4(1):67-71. doi: 10.1111/j.1365-2125.1977.tb00669.x.
Zotero 插件