与安慰剂相比，克仑特罗和特布他林对心脏、肺部及神经肌肉的影响。
Cardiac, pulmonary and neuromuscular effects of clenbuterol and terbutaline compared with placebo.
作者信息
Whitsett T L, Manion C V, Wilson M F
出版信息
Br J Clin Pharmacol. 1981 Aug;12(2):195-200. doi: 10.1111/j.1365-2125.1981.tb01200.x.
Abstract
1 Cardiac, neuromuscular (tremor) and pulmonary effects of multiple single oral doses of clenbuterol (40, 60 and 80 micrograms) and terbutaline (2.5 and 5 mg) were compared with placebo in thirteen patients with reversible obstructive airways disease. 2 The percent change in the bronchodilator and neuromuscular effects of clenbuterol and terbutaline were greater than that of the cardiac activity. 3 Both drugs decreased T wave amplitude and occasionally caused J point ST segment depression. These changes were considered typical of this class of drugs and clinically insignificant. 4 While these drugs had comparable cardiac, pulmonary and neuromuscular effects, clenbuterol, at larger doses, had a higher incidence of transient headaches and nervousness.
摘要
- 在13例可逆性阻塞性气道疾病患者中，比较了多次单次口服不同剂量克仑特罗（40、60和80微克）和特布他林（2.5和5毫克）与安慰剂对心脏、神经肌肉（震颤）和肺部的影响。2. 克仑特罗和特布他林的支气管扩张和神经肌肉效应的变化百分比大于心脏活动的变化百分比。3. 两种药物均降低T波振幅，偶尔引起J点ST段压低。这些变化被认为是这类药物的典型表现，临床上无显著意义。4. 虽然这些药物在心脏、肺部和神经肌肉方面有相似的作用，但大剂量的克仑特罗出现短暂头痛和紧张的发生率更高。
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