Czerniak B, Herz F, Wersto R P, Koss L G
Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467.
Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4860-3. doi: 10.1073/pnas.89.11.4860.
Computer-assisted image analysis was used to demonstrate in exponentially proliferating human tumor cells the uneven postmitotic apportionment of several oncogene-encoded proteins (ras p21; erbB-2 p185; fos p55; myc p62). This observation may provide the explanation for the high degree of heterogeneity of postmitotic cells and the asynchrony in cell cycle traverse of cultured cells.
利用计算机辅助图像分析技术，在指数增殖的人类肿瘤细胞中证实了几种癌基因编码蛋白（ras p21；erbB-2 p185；fos p55；myc p62）在有丝分裂后分配不均。这一观察结果可能为有丝分裂后细胞的高度异质性以及培养细胞在细胞周期进程中的不同步性提供了解释。
