Biosynthetic precursors of deazaflavins.
作者信息
Reuke B, Korn S, Eisenreich W, Bacher A
机构信息
Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Garching, Germany.
出版信息
J Bacteriol. 1992 Jun;174(12):4042-9. doi: 10.1128/jb.174.12.4042-4049.1992.
Abstract
The incorporation of 13C- and 14C-labeled precursors into 5-deaza-7,8-didemethyl-8-hydroxyriboflavin (factor F0) was studied with growing cells of Methanobacterium thermoautotrophicum. 5-Amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione was incorporated into the deazaflavin and into riboflavin without dilution. Tyrosine and 4-hydroxyphenylpyruvate were incorporated into the deazaflavin and into cellular protein. 4-Hydroxybenzaldehyde was not incorporated. A reaction mechanism is proposed for the formation of the deazaflavin chromophore from 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione and tyrosine or 4-hydroxyphenylpyruvate.
摘要
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