Toyoshima K, Akiyama T
Dept. of Oncogene Research, Institute for Microbial Diseases, Osaka University, Japan.
Gan To Kagaku Ryoho. 1992 Jun;19(6):751-6.
Recent progress in molecular biology of cancer revealed that mutations which potentiate the activities of proto-oncogenes create the oncogenes to force the growth of tumor cells. On the other hand, inactivation of antioncogenes results in the generations of tumor cells. The progression of many tumors to full malignancy requires both types of changes of the tumor cell genome.
癌症分子生物学的最新进展表明，增强原癌基因活性的突变会产生癌基因，从而促使肿瘤细胞生长。另一方面，抗癌基因的失活会导致肿瘤细胞的产生。许多肿瘤发展为完全恶性肿瘤需要肿瘤细胞基因组发生这两种类型的变化。
