Eichner H, Eichner V, Fiedler F, Hochstrasser K
Laryngol Rhinol Otol (Stuttg). 1976 Mar;55(3):239-44.
Kallikrein is an important mediator in microcirculation. Therefore, this work has been concerned with the excretion of kallikrein from human parotid glands. In 40 healthy persons kallikrein concentrations in resting parotid saliva were estimated. Subsequently, the glands were stimulated either by ascorbic acid or by subcutaneous injection of pilocarpin and the changes in BAEE-esterase activity were measured. The results show a significant increase of excreted enzyme on stimulation. Continuous stimulation, however, leads to exhaustion of the capacity of the glands within 40 min. After cessation of stimulation basal secretion rates are restored in the next 15 min. Kallikrein secretion is compared to the secretion of total protein, lysozym and immunglobulin A.
激肽释放酶是微循环中的一种重要介质。因此，这项研究关注的是人类腮腺中激肽释放酶的排泄情况。对40名健康人静息腮腺唾液中的激肽释放酶浓度进行了测定。随后，通过注射抗坏血酸或皮下注射毛果芸香碱刺激腺体，并测量BAEE酯酶活性的变化。结果显示，刺激后排泄酶显著增加。然而，持续刺激会导致腺体在40分钟内耗尽其分泌能力。刺激停止后，基础分泌率在接下来的15分钟内恢复。将激肽释放酶的分泌与总蛋白、溶菌酶和免疫球蛋白A的分泌进行了比较。
