Offerhaus G J, Tersmette A C, Giardiello F M, Huibregtse K, Vandenbroucke J P, Tytgat G N
Department of Pathology, Academic Medical Centre, Amsterdam, Netherlands.
Lancet. 1992 Jul 4;340(8810):33-5. doi: 10.1016/0140-6736(92)92433-g.
The value of endoscopic surveillance of postgastrectomy patients for the early detection of gastric-stump cancer is controversial. Using data from an Amsterdam postgastrectomy cohort of 2633 patients, we have done a retrospective analysis of the effect on mortality from gastric cancer of endoscopic surveillance in these patients. Between 1976 and 1982, 504 symptom-free patients from the Amsterdam cohort participated in an endoscopic surveillance programme. All patients were followed up until 1988. Relative to the general Dutch population, risk of death from gastric cancer was less among patients who took part in surveillance than among those who did not participate. However, differences were small and similar differences existed for risk of death from lung and colorectal cancers, suggesting the presence of selection. Our study seems to confirm that large-scale surveillance of postgastrectomy patients is not justified.
胃切除术后患者进行内镜监测以早期发现残胃癌的价值存在争议。利用来自阿姆斯特丹2633例胃切除术后患者队列的数据,我们对这些患者进行内镜监测对胃癌死亡率的影响进行了回顾性分析。1976年至1982年期间,来自阿姆斯特丹队列的504例无症状患者参加了内镜监测项目。所有患者均随访至1988年。与荷兰普通人群相比,参加监测的患者死于胃癌的风险低于未参加者。然而,差异很小,肺癌和结直肠癌的死亡风险也存在类似差异,提示存在选择偏倚。我们的研究似乎证实,对胃切除术后患者进行大规模监测是不合理的。