Kujath P, Eckmann C, Broll R, Woltmann A, Hohlbach G
Klinik für Chirurgie, Medizinische Universität, Lübeck.
Langenbecks Arch Chir. 1995;380(2):108-14. doi: 10.1007/BF00186417.
The results of a retrospective analysis of cases of gastric stump cancer are reported. Among 298 gastric carcinomas treated between 1. 1. 1986 and 1. 3. 1994, we found 28 (9.5%) cases of gastric stump cancer. Gastric carcinoma showed a male preponderance, with a male:female ratio of ca. 4:1. Two thirds of the patients were older than 70 years at the time of diagnosis. In 27 of 28 patients the original operation performed was a Billroth II resection without Braun's enteroanastomosis. The mean time lag before the development of gastric stump cancer was significantly shorter in the group of patients older than 45 years at the time of first operation (n = 16) than in patients 45 years or younger (n = 12, P = 0.03). Endoscopy with biopsy and endosonography were highly reliable diagnostic instruments. The capability of CT for recognizing lymphatic metastasis is poor (42.1% sensitivity). The main risk factors for the development of gastric stump cancer, according to our data, are male sex, Billroth II resection for first reconstruction, age over 45 years at first operation, and gastric ulcer as reason for the original gastric resection. The cost benefit ratio and timing of endoscopic screening of partially gastrectomized patients are discussed.
报告了胃残端癌病例的回顾性分析结果。在1986年1月1日至1994年3月1日期间治疗的298例胃癌中,我们发现28例(9.5%)胃残端癌。胃癌男性居多,男女比例约为4:1。三分之二的患者在诊断时年龄超过70岁。28例患者中有27例最初施行的手术是未行布朗氏肠吻合术的毕罗氏Ⅱ式切除术。首次手术时年龄超过45岁的患者组(n = 16)发生胃残端癌前的平均时间间隔明显短于45岁及以下的患者组(n = 12,P = 0.03)。内镜检查加活检及内镜超声检查是高度可靠的诊断手段。CT识别淋巴结转移的能力较差(敏感性为42.1%)。根据我们的数据,胃残端癌发生的主要危险因素为男性、首次重建采用毕罗氏Ⅱ式切除术、首次手术时年龄超过45岁以及胃溃疡作为最初胃切除的原因。还讨论了部分胃切除患者内镜筛查的成本效益比及时机。