Reinert M, Kiefer R
Laryngol Rhinol Otol (Stuttg). 1976 Jun;55(6):482-6.
In 64 out-patients suffering from perennial and partly from additional saisonal rhinopathia correlations between clinical history, skin testing (prick test) and nasal provocation tests were investigated. Most patients showed several positive skin tests to common allergens particular to grass pollen, house dust and mites (Dermatophagoides pteronyssimus). 123 nasal provocation tests were done. The correlation between history and skin test or nasal challenge was very strong for grass pollen (agreement in 78%), but very unsatisfctory for house dust and mites. Even in patients with positive skin tests to house dust and mites the history was only positive in 50-60%. Therefore the diagnose of perennial rhinopathia due to house dust and/or mites is only relevant if the nasal provocation gives a positive result. But if skin test are negative, nasal allergen challenge seldom showed positive reactions. For practical purpose nasal provocation is unneccessary if the skin test is negative. But the nasal provocation test don't give an absolutely right diagnose, because neither the environmental concentration nor the nasal threshold generally are known. Therefore, it is difficult to decide in many cases, if a reaction is positive because of testing a relevant allergen or because a latent allergen was overdosed. Finally the investigations show that simple and reproducible methods like the nasal forced expiratory volume in one second are sufficient to detect a positive nasal reaction.
对64例常年性鼻炎患者（部分患者还伴有季节性鼻炎）进行了临床病史、皮肤试验（点刺试验）和鼻激发试验之间相关性的研究。大多数患者对草花粉、屋尘和螨虫（粉尘螨）等常见过敏原的皮肤试验呈阳性。共进行了123次鼻激发试验。草花粉的病史与皮肤试验或鼻激发试验之间的相关性很强（符合率为78%），但屋尘和螨虫的相关性非常不理想。即使对屋尘和螨虫皮肤试验呈阳性的患者，其病史呈阳性的比例也仅为50% - 60%。因此，只有鼻激发试验呈阳性时，因屋尘和/或螨虫导致的常年性鼻炎诊断才具有相关性。但如果皮肤试验为阴性，鼻过敏原激发试验很少出现阳性反应。出于实际目的，如果皮肤试验为阴性，则无需进行鼻激发试验。但鼻激发试验并不能给出绝对正确的诊断，因为环境浓度和鼻阈通常都不清楚。因此，在许多情况下，很难确定反应呈阳性是因为检测到了相关过敏原，还是因为潜在过敏原剂量过大。最后，研究表明，像一秒用力呼气量这样简单且可重复的方法足以检测到阳性鼻反应。
