Mitchell B S, Ahmed E
Faculty of Medicine, University of Southampton, UK.
Histochem J. 1992 Jun;24(6):361-7. doi: 10.1007/BF01046168.
The uterus and vagina of the guinea pig have been examined, region by region, for acetylcholinesterase, tyrosine hydroxylase, dopamine beta-hydroxylase and aromatic amino acid decarboxylase activity, as well as for the neuropeptides, neuropeptide Y, vasoactive intestinal peptide, substance P, enkephalin and somatostatin. No acetylcholinesterase activity was localized in the uterus, though it was present in associated paracervical ganglion tissues. Of the catecholamine-synthesizing enzymes, tyrosine hydroxylase and dopamine beta-hydroxylase activity was found virtually throughout the reproductive tract, whereas aromatic amino acid decarboxylase activity was restricted in its distribution. Neuropeptide distribution was quite varied. Neuropeptide Y was found throughout the endometrium/submucosa but only in the muscularis of the vagina and not in the myometrium. Substance P was localized in the vagina and uterine horn, though not the body of the uterus. Vasoactive intestinal peptide was present in all regions of the endometrium/submucosa, but not in the myometrium of the uterine horn. Enkephalin and somatostatin were not localized in any part of the reproductive tract examined, apart from paracervical ganglion tissues. The types and significance of the nerves supplying the reproductive tract are discussed.
对豚鼠的子宫和阴道进行了逐区域检查，以检测乙酰胆碱酯酶、酪氨酸羟化酶、多巴胺β羟化酶和芳香族氨基酸脱羧酶的活性，以及神经肽、神经肽Y、血管活性肠肽、P物质、脑啡肽和生长抑素。子宫中未检测到乙酰胆碱酯酶活性，不过在相关的子宫颈旁神经节组织中存在该酶活性。在儿茶酚胺合成酶中，酪氨酸羟化酶和多巴胺β羟化酶活性几乎在整个生殖道中都能检测到，而芳香族氨基酸脱羧酶活性的分布则受到限制。神经肽的分布差异很大。神经肽Y在整个子宫内膜/黏膜下层均有发现，但仅在阴道肌层中存在，子宫肌层中未发现。P物质定位于阴道和子宫角，但子宫体中未发现。血管活性肠肽存在于子宫内膜/黏膜下层的所有区域，但子宫角的子宫肌层中未发现。除子宫颈旁神经节组织外，在所检查的生殖道任何部位均未发现脑啡肽和生长抑素。本文讨论了供应生殖道的神经类型及其意义。
