Holle G E, Steinbach E, Forth W
Walther Straub Institute for Pharmacology and Toxicology, Ludwig Maximilian University, Munich, Federal Republic of Germany.
Am J Physiol. 1992 Jul;263(1 Pt 1):G52-9. doi: 10.1152/ajpgi.1992.263.1.G52.
The effects of erythromycin on motor and electrical behavior of the antrum, pylorus, and duodenum were determined in chronically instrumented, awake dogs. Erythromycin infusion resulted in an abrupt, powerful increase in motility. The motility index increased 18-fold in the antrum, 15-fold in the pylorus, and 8-fold in the duodenum. Bradyarrhythmia with a 30% decrease in slow-wave frequency occurred in all animals. Retrograde giant contractions in association with retching and vomiting occurred in 88% of the dogs. Neostigmine was less potent than erythromycin in increasing motility. Hexamethonium given intra-arterially during erythromycin infusion abolished motility for 7.2 +/- 2.9 min and intra-arterial atropine did so for 51 +/- 25 min. Hexamethonium or atropine restored the electrical slow-wave frequency. The results provide evidence that erythromycin action involves cholinergic pathways including ganglionic transmission.
在长期植入仪器的清醒犬中，测定了红霉素对胃窦、幽门和十二指肠的运动及电活动的影响。输注红霉素导致运动突然剧烈增加。胃窦的运动指数增加了18倍，幽门增加了15倍，十二指肠增加了8倍。所有动物均出现缓慢性心律失常，慢波频率降低30%。88%的犬出现与干呕和呕吐相关的逆行性巨大收缩。新斯的明在增加运动方面的效力低于红霉素。在输注红霉素期间动脉内给予六甲铵可使运动停止7.2±2.9分钟，动脉内给予阿托品则可使运动停止51±25分钟。六甲铵或阿托品可恢复电慢波频率。结果表明，红霉素的作用涉及胆碱能途径，包括神经节传递。
