Kobayashi S, Iwase H, Itoh Y, Fukuoka H, Yamashita H, Kuzushima T, Iwata H, Masaoka A, Kimura N
Second Department of Surgery, Nagoya City University Medical School.
Jpn J Cancer Res. 1992 Aug;83(8):859-65. doi: 10.1111/j.1349-7006.1992.tb01991.x.
Expression of the c-erbB-2 oncoprotein (ErbB-2) and the nm23 anti-metastatic gene product (nucleoside diphosphate [NDP] kinase) was examined in the intraductal and invasive components of 63 fresh human breast cancer tissues. The expression of estrogen receptor (ER) as a marker of hormone dependency and the Ki-67 protein as a proliferative cell marker was also examined. ErbB-2 and ER were positive in 77.8% (28/36) and 64.7% (22/34) of the intraductal components, and in 43.6% (27/62) and 57.1% (36/63) of the invasive components, respectively. NDP kinase was positive in 58% (18/31) of intraductal, and in 30.9% (17/55) of invasive areas. The average Ki-67-positive cell rates were 5.9% in the intraductal, and 10.7% in the invasive components. Thus, the cells within the intraductal component of breast cancer appear to have different characteristics from the invasive component, not only in markers of proliferative ability, but also in the expression of oncogenes and hormone receptors.
在63例新鲜人乳腺癌组织的导管内成分和浸润成分中检测了c-erbB-2癌蛋白（ErbB-2）和nm23抗转移基因产物（核苷二磷酸激酶）的表达。还检测了作为激素依赖性标志物的雌激素受体（ER）的表达以及作为增殖细胞标志物的Ki-67蛋白的表达。ErbB-2和ER在导管内成分中的阳性率分别为77.8%（28/36）和64.7%（22/34），在浸润成分中的阳性率分别为43.6%（27/62）和57.1%（36/63）。核苷二磷酸激酶在导管内成分中的阳性率为58%（18/31），在浸润区域中的阳性率为30.9%（17/55）。导管内成分的平均Ki-67阳性细胞率为5.9%，浸润成分的平均Ki-67阳性细胞率为10.7%。因此，乳腺癌导管内成分中的细胞似乎不仅在增殖能力标志物方面，而且在癌基因和激素受体表达方面都与浸润成分具有不同的特征。
