Schwartz J J, Myskowski P L
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
J Am Acad Dermatol. 1992 Oct;27(4):583-8. doi: 10.1016/0190-9622(92)70226-6.
Molluscum contagiosum (MC) is a common and at times severely disfiguring cutaneous viral infection in patients with human immunodeficiency virus (HIV) infection.
The purpose of this study was to describe the clinical course of MC in patients with HIV infection and to examine the relation between presentation of MC and the stage of HIV infection, as measured by T-cell subsets.
This is a retrospective case study of 27 patients with MC and HIV infection who had T-cell subset determination within 60 days of diagnosis of MC.
The overall mean CD4+ count, CD4+ percentage, and CD4+/CD8+ ratio were 85.7/mm3, 5.9%, and 0.10, respectively. An inverse relation between CD4+ count and the number of MC lesions was observed (p = 0.0023). Fourteen patients (52%) had facial and neck lesions alone, and seven (26%) had lesions in areas associated with sexual transmission. Pneumocystis carinii pneumonia had occurred in 8 patients (31%) and Kaposi's sarcoma in 15 patients (56%).
MC can occur as a late manifestation of HIV infection and is a cutaneous correlate of cellular immune deficiency.
传染性软疣（MC）是人类免疫缺陷病毒（HIV）感染患者中一种常见且有时会导致严重毁容的皮肤病毒感染。
本研究的目的是描述HIV感染患者中MC的临床病程，并通过T细胞亚群检测MC的表现与HIV感染阶段之间的关系。
这是一项对27例MC合并HIV感染患者的回顾性病例研究，这些患者在MC诊断后60天内进行了T细胞亚群测定。
总体平均CD4 +细胞计数、CD4 +百分比和CD4 + / CD8 +比值分别为85.7 / mm3、5.9%和0.10。观察到CD4 +细胞计数与MC皮损数量之间呈负相关（p = 0.0023）。14例患者（52%）仅面部和颈部有皮损，7例患者（26%）在与性传播相关的部位有皮损。8例患者（31%）发生了卡氏肺孢子虫肺炎，15例患者（56%）发生了卡波西肉瘤。
MC可作为HIV感染的晚期表现出现，是细胞免疫缺陷的皮肤相关表现。
