Wilson D A, Wood J G
Department of Psychology, University of Oklahoma, Norman 73019.
Neuroscience. 1992 Jul;49(1):183-92. doi: 10.1016/0306-4522(92)90086-h.
Unilateral olfactory deprivation in the rat profoundly modifies olfactory bulb anatomy, chemistry and function. The present report examined the time-course of the functional effects of unilateral deprivation on inhibition in the olfactory bulb using paired-pulse stimulation of the lateral olfactory tract and olfactory nerve. In addition, an attempt was made to correlate these physiological measures with olfactory bulb dopamine and norepinephrine levels and tyrosine hydroxylase immunoreactivity. Deprivation from postnatal day 1 to postnatal day 20 or postnatal day 40 significantly enhanced lateral olfactory tract paired-pulse depression, while late onset deprivation (postnatal day 20) had no effect. Olfactory nerve paired-pulse depression was enhanced by 40 days of deprivation regardless of the age at onset. The time-course of these deprivation-induced physiological changes did not correlate well with reductions in dopamine. Dopamine levels were reduced in all deprivation conditions by 70-80% compared with control bulbs. Norepinephrine content was slightly elevated in deprived bulbs. These results suggest that early olfactory deprivation modifies olfactory bulb synaptic activity and further, as with other sensory systems, these effects are age and duration dependent.
大鼠单侧嗅觉剥夺会深刻改变嗅球的解剖结构、化学组成和功能。本报告利用对侧嗅束和嗅神经的双脉冲刺激，研究了单侧剥夺对嗅球抑制作用的功能影响的时间进程。此外，还尝试将这些生理指标与嗅球多巴胺、去甲肾上腺素水平以及酪氨酸羟化酶免疫反应性进行关联。从出生后第1天到出生后第20天或第40天进行剥夺，显著增强了对侧嗅束双脉冲抑制，而晚期开始剥夺（出生后第20天）则没有影响。无论开始剥夺的年龄如何，40天的剥夺都会增强嗅神经双脉冲抑制。这些剥夺诱导的生理变化的时间进程与多巴胺的减少没有很好的相关性。与对照嗅球相比，在所有剥夺条件下多巴胺水平都降低了70 - 80%。去甲肾上腺素含量在剥夺的嗅球中略有升高。这些结果表明，早期嗅觉剥夺会改变嗅球突触活动，而且，与其他感觉系统一样，这些影响取决于年龄和持续时间。
