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功能性嗅觉剥夺对大鼠主嗅球中γ-氨基丁酸能和儿茶酚胺能特征的差异影响。

Differential effect of functional olfactory deprivation on the GABAergic and catecholaminergic traits in the rat main olfactory bulb.

作者信息

Kosaka T, Kosaka K, Hama K, Wu J Y, Nagatsu I

出版信息

Brain Res. 1987 Jun 9;413(1):197-203. doi: 10.1016/0006-8993(87)90171-5.

DOI:10.1016/0006-8993(87)90171-5
PMID:2885074
Abstract

The effects of the unilateral olfactory naris closure were studied immunohistochemically in the main olfactory bulb of adult rats. In the olfactory deprived bulbs, the tyrosine hydroxylase-immunoreactive elements in the glomeruli and the juxtaglomerular region decreased drastically, whereas the glutamate decarboxylase-immunoreactive elements in these regions showed no appreciable changes, indicating the differential effects of olfactory deprivation on catecholaminergic and GABAergic traits in spite of their coexistence in some neurons in these regions.

摘要

在成年大鼠的主嗅球中,通过免疫组织化学方法研究了单侧嗅鼻孔封闭的影响。在嗅觉剥夺的嗅球中,肾小球和肾小球旁区域中酪氨酸羟化酶免疫反应性元素急剧减少,而这些区域中谷氨酸脱羧酶免疫反应性元素没有明显变化,这表明尽管嗅觉剥夺对这些区域某些神经元中共存的儿茶酚胺能和GABA能特征有不同影响。

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