Wilson D A, Guthrie K M, Leon M
Department of Psychology, University of Oklahoma, Norman 73019.
Neurosci Lett. 1990 Aug 24;116(3):250-6. doi: 10.1016/0304-3940(90)90082-k.
Early unilateral olfactory deprivation produces large structural and neurochemical changes in the olfactory bulb, the first central relay for olfactory information. The functioning of deprived bulbs was examined in the present report by using paired-pulse stimulation of the lateral olfactory tract. Paired-pulse stimulation reflects interactions between mitral/tufted cells and granule cells, as well as the modulatory effects of centrifugal and intra-bulbar association fibers. Paired-pulse stimulation produced inhibition of mitral/tufted cells in control animals at PN20-PN22. This inhibition was significantly enhanced in littermates deprived of olfactory input from PN1 to PN20-PN22. Suppression of mitral/tufted cell single-unit spontaneous activity following single-pulse stimulation of the lateral olfactory tract (LOT) was similarly enhanced in deprived bulbs. These results suggest that early olfactory deprivation significantly modifies subsequent olfactory system function.
早期单侧嗅觉剥夺会在嗅球（嗅觉信息的首个中枢中继站）产生巨大的结构和神经化学变化。在本报告中，通过对外侧嗅束进行双脉冲刺激来检测被剥夺嗅觉的嗅球的功能。双脉冲刺激反映了僧帽/簇状细胞与颗粒细胞之间的相互作用，以及离心和球内联合纤维的调节作用。在PN20 - PN22的对照动物中，双脉冲刺激对僧帽/簇状细胞产生抑制作用。在从PN1至PN20 - PN22被剥夺嗅觉输入的同窝幼崽中，这种抑制作用显著增强。在被剥夺嗅觉的嗅球中，外侧嗅束（LOT）单脉冲刺激后僧帽/簇状细胞单单位自发活动的抑制同样增强。这些结果表明，早期嗅觉剥夺会显著改变后续嗅觉系统的功能。
