Amorim C Z, Cordeiro R S, Vargaftig B B
Fundação Oswaldo Cruz, IOC, Departamento de Fisiologia e Farmacodinâmica, Rio de Janeiro, Brazil.
Eur J Pharmacol. 1992 Jun 17;216(3):429-34. doi: 10.1016/0014-2999(92)90441-6.
The protective effects of two antihistamines and two anti-allergic drugs against anaphylactic paw edema were studied in immunized animals that had or had not received a booster injection of antigen. The injection of 1 or 10 micrograms/paw ovalbumin induced acute paw edema of similar intensity in both groups. The antihistamine meclizine and the mixed anti histamine/anti-5-HT antagonist cyproheptadine reduced the anaphylactic reaction by 55 and 84% respectively, in non-boosted animals and were less effective against edema induced by 1 microgram antigen in boosted animals. The effectiveness of these drugs was also reduced when boosted mice were challenged with 10 micrograms antigen, where meclizine and cyproheptadine inhibited edema by 31 and 59%, respectively. The anti-allergic compounds ketotifen and azelastine, although effective against allergic inflammation in non-boosted mice, had a reduced or no effect in boosted mice. Our results suggest that allergic edema is less sensitive to antihistamine and anti-allergic drugs in boosted mice, which may be accounted for by an increased role of other mediators.
在已接受或未接受抗原加强注射的免疫动物中，研究了两种抗组胺药和两种抗过敏药对过敏性爪肿胀的保护作用。在两组动物中，每爪注射1或10微克卵清蛋白均诱发了强度相似的急性爪肿胀。抗组胺药美克洛嗪以及抗组胺/抗5-羟色胺混合拮抗剂赛庚啶，在未接受加强注射的动物中分别使过敏反应降低了55%和84%，而在接受加强注射的动物中，它们对1微克抗原诱发的肿胀效果较差。当用10微克抗原攻击接受加强注射的小鼠时，这些药物的有效性也降低了，其中美克洛嗪和赛庚啶分别抑制肿胀31%和59%。抗过敏化合物酮替芬和氮卓斯汀，虽然对未接受加强注射的小鼠的过敏性炎症有效，但在接受加强注射的小鼠中作用减弱或无效。我们的结果表明，在接受加强注射的小鼠中，过敏性肿胀对抗组胺药和抗过敏药不太敏感，这可能是由于其他介质的作用增强所致。
