Amorim C Z, Cordeiro R S, Vargaftig B B
Fundação Oswaldo Cruz, IOC, Departamento de Fisiologia e Farmacodinâmica, Rio de Janeiro, Brazil.
Eur J Pharmacol. 1993 May 19;236(2):301-4. doi: 10.1016/0014-2999(93)90602-e.
The interference of the novel platelet-activating factor (PAF) receptor antagonist compound PCA 4248 with paw edema induced by antigen in sensitized boosted or unboosted mice was studied. Although PAF-induced edema was of similar intensity in non-sensitized and in both groups of sensitized mice, PCA 4248 was less effective in inhibiting paw edema induced by PAF in boosted mice. Paw edema induced by antigen in unboosted mice was refractory to PCA 4248 under conditions where edema in boosted mice was inhibited. Our results demonstrate that the PCA 4248 displays an anti-PAF activity in non-sensitized mice that is reduced by the booster injection of antigen. PAF plays an important role in the anaphylactic edema in boosted but not in unboosted mice.
研究了新型血小板活化因子（PAF）受体拮抗剂化合物PCA 4248对致敏加强或未加强小鼠抗原诱导的爪部水肿的干扰作用。尽管PAF诱导的水肿在未致敏小鼠和两组致敏小鼠中强度相似，但PCA 4248在抑制加强小鼠中PAF诱导的爪部水肿方面效果较差。在抑制加强小鼠水肿的条件下，未加强小鼠中抗原诱导的爪部水肿对PCA 4248不敏感。我们的结果表明，PCA 4248在未致敏小鼠中表现出抗PAF活性，而抗原加强注射会降低这种活性。PAF在加强小鼠的过敏性水肿中起重要作用，但在未加强小鼠中不起作用。
