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[22小时太空飞行后大鼠心肌中的蛋白质组分及其酶活性]

[Protein fractions and their enzyme activity in rat myocardium after a 22-hour space flight].

作者信息

Gaevskaia M S, Veresotskaia N A, Kolganova N S, Kolchina E V, Kurkina L M

出版信息

Kosm Biol Aviakosm Med. 1976 Sep-Oct;10(5):37-40.

PMID:135882
Abstract

No significant changes in the content of sarcoplasmatic and myofibrillar proteins were found in the myocardium of rats that made a 22-day flight onboard the biosatellite. On the 2nd and 26th postflight days the activity of aspartate and alanine aminotransferases of sarcoplasmatic proteins was increased and the total activity of lactate dehydrogenase and its isoenzyme spectrum remained unchanged. On the 2nd postflight day the ATPase activity of myosin of the myocardium was substantially lowered and on the 26th postflight day it returned to the normal. This decline in the ATPase activity of myosin can be regarded as an adaptive reaction to weightlessness.

摘要

在生物卫星上进行了22天飞行的大鼠心肌中,未发现肌浆蛋白和肌原纤维蛋白含量有显著变化。在飞行后第2天和第26天,肌浆蛋白中天冬氨酸和丙氨酸转氨酶的活性增加,乳酸脱氢酶的总活性及其同工酶谱保持不变。在飞行后第2天,心肌肌球蛋白的ATP酶活性大幅降低,在飞行后第26天恢复正常。肌球蛋白ATP酶活性的这种下降可被视为对失重的一种适应性反应。

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