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[宇宙-690生物卫星飞行后大鼠心肌中的蛋白质组分及其酶活性]

[Protein fractions and their enzymatic activity in the rat myocardium after a flight on the Cosmos-690 biosatellite].

作者信息

Gaevskaia M S, Kolchina E V, Nosova E A, Kolganova N S, Veresotskaia N A

出版信息

Kosm Biol Aviakosm Med. 1978 Sep-Oct;12(5):12-5.

PMID:692062
Abstract

Gamma-irradiation of rats in the ground-based experiment decreased the activity of aspartate aminotransferase of sarcoplasmatic proteins of the myocardium and increased the activity of adenosine triphosphate of myosin of the myocardium 1 and 26 days post-test. Gamma-irradiation of flight rats also reduced the activity of aspartate aminotransferase of sarcoplasmatic proteins of the myocardium; however, the activity of ATPase of myosin of the myocardium was lowered both 1 and 26 days postflight. It is suggested that irradiation-induced inhibition of synthetic processes delayed the synthesis of myosin with a normal activity and diminished the protein content in the T fraction of myocardium on the 1st postflight day.

摘要

在地面实验中,对大鼠进行γ射线照射后,在测试后1天和26天,心肌肌浆蛋白中天冬氨酸转氨酶的活性降低,而心肌肌球蛋白中三磷酸腺苷的活性增加。对飞行后的大鼠进行γ射线照射也降低了心肌肌浆蛋白中天冬氨酸转氨酶的活性;然而,在飞行后1天和26天,心肌肌球蛋白的ATP酶活性均降低。有研究表明,辐射诱导的合成过程抑制延缓了具有正常活性的肌球蛋白的合成,并在飞行后第1天减少了心肌T组分中的蛋白质含量。

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