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[“宇宙-690”生物卫星飞行后大鼠比目鱼肌组织代谢的变化]

[Changes in the soleus muscle tissue metabolism of rats after a flight on the Kosmos-690 biosatellite].

作者信息

Gaevskaia M S, Veresotskaia N A, Kolganova N S, Kolchina E V, Kurkina L M

出版信息

Kosm Biol Aviakosm Med. 1979 Jan-Feb;13(1):16-9.

PMID:423507
Abstract

The soleus muscle of flown rats did not show any effect of gamma-irradiation on the composition and enzymic activity of protein fractions. On the Ist postflight day a significant decrease in the content of myofibrillar and sarcoplasmatic proteins in the soleus muscle was found. Besides, a drastic increase in the activity of aspartate aminotransferase and lactate dehydrogenase of sarcoplasmatic proteins and an atrophic type change in the LDH pattern were demonstrated. Those changes were similar to the weighttlessness-induced processes of atrophy and dystrophy and proved reversible.

摘要

飞行大鼠的比目鱼肌未显示出γ射线辐射对蛋白质组分的组成和酶活性有任何影响。在飞行后的第1天,发现比目鱼肌中肌原纤维和肌浆蛋白的含量显著降低。此外,还证明了肌浆蛋白中天冬氨酸转氨酶和乳酸脱氢酶的活性急剧增加,以及乳酸脱氢酶模式出现萎缩型变化。这些变化与失重引起的萎缩和营养不良过程相似,并证明是可逆的。

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