Katoh K, Kawai T, Narita M, Uemura J, Tani K, Okubo T
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
J Pharm Pharmacol. 1992 May;44(5):442-4. doi: 10.1111/j.2042-7158.1992.tb03641.x.
Four patients with connective tissue disease who had been suffering from severe Raynaud's phenomenon were treated with an intravenous infusion of prostaglandin E1 (PGE1) and its effectiveness was assessed by thermography and a questionnaire approach. PGE1 in a lipid microsphere formulation (lipo-PGE1) produced a significantly greater increase in lesional skin temperature compared with treatment with PGE1 clathrated in alpha-cyclodextrin 12 months previously in the same group of patients. These results were supported by the subjective assessment obtained from the patients by questionnaire.
对4例患有严重雷诺现象的结缔组织病患者进行了前列腺素E1（PGE1）静脉输注治疗，并通过热成像和问卷调查的方法评估了其疗效。与12个月前在同一组患者中使用α-环糊精包合的PGE1治疗相比，脂质微球制剂（脂微球PGE1）使病变皮肤温度显著升高。这些结果得到了通过问卷调查从患者那里获得的主观评估的支持。
