Kyle V, Parr G, Salisbury R, Thomas P P, Hazleman B
Ann Rheum Dis. 1985 Feb;44(2):73-8. doi: 10.1136/ard.44.2.73.
This is the first study to show a quantitative thermographic difference between patients with Raynaud's syndrome and normal controls after cold stress testing. An improved thermographic response to cold stress testing after treatment of Raynaud's syndrome with PGE1 has also been shown for the first time. Discriminant analysis of the change in temperature of a finger after cold stress, and the mean thermal gradient along the finger during rewarming, clearly separated patients from controls. After treatment with PGE1 the patients' discriminant values moved into the normal range. Symptomatic improvement after PGE1 correlated well with thermographic improvement, and both persisted for up to 12 weeks.
这是第一项显示在冷应激测试后，雷诺综合征患者与正常对照者之间存在定量热成像差异的研究。首次还表明，用PGE1治疗雷诺综合征后，对冷应激测试的热成像反应有所改善。对冷应激后手指温度变化以及复温过程中沿手指的平均热梯度进行判别分析，能清晰地将患者与对照者区分开来。用PGE1治疗后，患者的判别值进入正常范围。PGE1治疗后的症状改善与热成像改善密切相关，且两者均持续长达12周。
