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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Institute of Physiology, University of Glasgow, U.K.

Comp Biochem Physiol Comp Physiol. 1992 Jul;102(3):425-32. doi: 10.1016/0300-9629(92)90189-w.

Regulation of intracellular and extracellular pH may conflict in their requirements for movement of acid or base. 2. Cells make a positive or a negative contribution to 'tissue buffering' of extracellular fluid (ECF), depending on their internal buffer value, on the tightness of their internal pH control by membrane mechanisms, and on the nature of the acid-base disturbance. 3. A role is suggested for electrogenic Na-HCO3 co-transport in some of the ion shifts that occur in acid-base disturbances. 4. The time course of 'tissue buffering' in nephrectomized mammals in hypercapnia is variable, and it is far from clear in intact, unanaesthetized mammals. 5. Buffering of ECF by Ca salts of bone mineral in acidosis can only be substantial if accompanied by Ca excretion; the release of HCO3 with Na and K is more significant. 6. The relative importance of cells and of bone mineral in the buffering of ECF is unclear.

细胞内和细胞外pH的调节在酸或碱移动的需求方面可能存在冲突。2. 细胞对细胞外液（ECF）的“组织缓冲”可产生正向或负向作用，这取决于其内部缓冲值、通过膜机制进行的内部pH控制的严格程度以及酸碱紊乱的性质。3. 有人提出在酸碱紊乱中发生的一些离子转移中，电中性的Na-HCO3协同转运发挥了作用。4. 肾切除的哺乳动物在高碳酸血症时“组织缓冲”的时间进程是可变的，在完整、未麻醉的哺乳动物中情况也远未明确。5. 酸中毒时骨矿物质的钙盐对ECF的缓冲作用只有在伴有钙排泄时才会显著；HCO3与Na和K的释放更为重要。6. 细胞和骨矿物质在ECF缓冲中的相对重要性尚不清楚。

Institute of Physiology, University of Glasgow, U.K.

Comp Biochem Physiol Comp Physiol. 1992 Jul;102(3):425-32. doi: 10.1016/0300-9629(92)90189-w.

Regulation of intracellular and extracellular pH may conflict in their requirements for movement of acid or base. 2. Cells make a positive or a negative contribution to 'tissue buffering' of extracellular fluid (ECF), depending on their internal buffer value, on the tightness of their internal pH control by membrane mechanisms, and on the nature of the acid-base disturbance. 3. A role is suggested for electrogenic Na-HCO3 co-transport in some of the ion shifts that occur in acid-base disturbances. 4. The time course of 'tissue buffering' in nephrectomized mammals in hypercapnia is variable, and it is far from clear in intact, unanaesthetized mammals. 5. Buffering of ECF by Ca salts of bone mineral in acidosis can only be substantial if accompanied by Ca excretion; the release of HCO3 with Na and K is more significant. 6. The relative importance of cells and of bone mineral in the buffering of ECF is unclear.

细胞内和细胞外pH的调节在酸或碱移动的需求方面可能存在冲突。2. 细胞对细胞外液（ECF）的“组织缓冲”可产生正向或负向作用，这取决于其内部缓冲值、通过膜机制进行的内部pH控制的严格程度以及酸碱紊乱的性质。3. 有人提出在酸碱紊乱中发生的一些离子转移中，电中性的Na-HCO3协同转运发挥了作用。4. 肾切除的哺乳动物在高碳酸血症时“组织缓冲”的时间进程是可变的，在完整、未麻醉的哺乳动物中情况也远未明确。5. 酸中毒时骨矿物质的钙盐对ECF的缓冲作用只有在伴有钙排泄时才会显著；HCO3与Na和K的释放更为重要。6. 细胞和骨矿物质在ECF缓冲中的相对重要性尚不清楚。