Glenney J R
Lucille P. Markey Cancer Center, Department of Surgery, University of Kentucky College of Medicine, Lexington 40536-0093.
FEBS Lett. 1992 Dec 7;314(1):45-8. doi: 10.1016/0014-5793(92)81458-x.
Caveolin is a protein present in membrane specializations termed caveolae where it may play a structural role. Previous studies on the cDNA sequence of chicken caveolin demonstrated that it is an integral membrane protein without significant homology to any known protein. The cDNA sequence of human lung caveolin is presented here. A striking sequence homology is observed with the chicken protein, as well as a very recently reported protein termed VIP21 [(1992) J. Cell Biol. 118, 1003-1014], a putative vesicle transport protein isolated from MDCK cells. Genomic Southern blots suggest that caveolin is present in a single copy, and Northern blots confirm that the caveolin mRNA is elevated in muscle.
小窝蛋白是一种存在于称为小窝的膜特化结构中的蛋白质，它可能在其中发挥结构作用。先前对鸡小窝蛋白cDNA序列的研究表明，它是一种整合膜蛋白，与任何已知蛋白质均无明显同源性。本文展示了人肺小窝蛋白的cDNA序列。观察到它与鸡蛋白以及最近报道的一种称为VIP21的蛋白质[(1992)《细胞生物学杂志》118, 1003 - 1014]有显著的序列同源性，VIP21是从MDCK细胞中分离出的一种假定的囊泡转运蛋白。基因组Southern杂交表明小窝蛋白以单拷贝形式存在，Northern杂交证实小窝蛋白mRNA在肌肉中表达升高。
