1 Grupo UNIMOL, Facultad de Medicina, Universidad de Cartagena , Cartagena de Indias, Colombia .
2 Departamento Médico, Facultad de Medicina, Universidad de Cartagena , Cartagena de Indias, Colombia .
Metab Syndr Relat Disord. 2018 Nov;16(9):453-463. doi: 10.1089/met.2018.0004. Epub 2018 May 15.
The caveolin 1 (CAV1) gene has been associated with metabolic traits in animal models and human cohorts. Recently, a prevalent variant in CAV1 has been found to be related to metabolic syndrome in Hispanics living in North America. Since Hispanics represent an admixed population at high risk for cardiovascular diseases, in this study a Latin American population with a similar genetic background was assessed.
To analyze a genetic association between CAV1 and metabolic traits in an admixed Latin American population.
A cross-sectional study was carried out with adults from the Colombian Caribbean Coast, selected in urban clusters and work places through a stratified sampling to include diverse ages and socioeconomic groups. Blood pressure and waist circumference were registered. Serum concentrations of glucose, triglycerides, and high-density lipoprotein cholesterol were measured from an 8-hr fasting whole-blood sample. Two previously analyzed CAV1 single nucleotide polymorphisms were genotyped (rs926198 and rs11773845). A logistic regression model was applied to estimate the associations. An admixture adjustment was performed through a Bayesian model.
A total of 605 subjects were included. rs11773845 was associated with hypertriglyceridemia [odds ratio (OR) = 1.33, p = 0.001] and the metabolic syndrome (OR = 1.53, p = 0.02). When admixture adjustment was performed these genetic associations preserved their statistical significance. There were no significant associations between rs926198 and metabolic traits.
The CAV1 variation rs11773845 was found to be consistently associated with high serum triglycerides and the metabolic syndrome. This is the first report of a relationship between CAV1 variants and serum triglycerides in Latin America.
caveolin 1（CAV1）基因与动物模型和人类队列的代谢特征有关。最近，在居住在北美的西班牙裔人群中发现 CAV1 的一种常见变体与代谢综合征有关。由于西班牙裔是心血管疾病高危的混合人群，因此在这项研究中，评估了具有相似遗传背景的拉丁美洲人群。
分析混合拉丁美洲人群中 CAV1 与代谢特征的遗传关联。
对来自哥伦比亚加勒比海岸的成年人进行了一项横断面研究，通过分层抽样在城市集群和工作场所中选择成年人，以纳入不同年龄和社会经济群体。记录血压和腰围。从禁食 8 小时的全血样本中测量血清葡萄糖、甘油三酯和高密度脂蛋白胆固醇浓度。对先前分析的两个 CAV1 单核苷酸多态性（rs926198 和 rs11773845）进行基因分型。应用逻辑回归模型估计关联。通过贝叶斯模型进行混合调整。
共纳入 605 名受试者。rs11773845 与高甘油三酯血症相关[比值比（OR）=1.33，p=0.001]和代谢综合征（OR=1.53，p=0.02）。当进行混合调整时，这些遗传关联仍然具有统计学意义。rs926198 与代谢特征之间没有显著关联。
CAV1 变异 rs11773845 与高血清甘油三酯和代谢综合征持续相关。这是首次报道 CAV1 变体与拉丁美洲血清甘油三酯之间的关系。
