Bani D, Brandi M L, Axiotis C A, Bani-Sacchi T
Department of Human Anatomy and Histology, University of Florence, Italy.
Histochemistry. 1992 Nov;98(4):207-9. doi: 10.1007/BF00271033.
P-glycoprotein, an integral membrane protein acting as an energy-dependent efflux pump, has been detected immunocytochemically in the human pancreatic islets using C 494 monoclonal antibody. Intense P-glycoprotein immunoreactivity was found in both endothelial cells of islet blood capillaries and in endocrine cells. Strong expression of P-glycoprotein has been found in the capillary blood vessels at blood-tissue barrier sites and in numerous kinds of cells with secretory/excretory function. Therefore the present findings suggest that P-glycoprotein may play a role in controlling the composition of the extracellular fluids and the intracellular milieu of endocrine islet cells and possibly in regulating their secretory activity.
P-糖蛋白是一种作为能量依赖型外排泵的整合膜蛋白，利用C 494单克隆抗体已通过免疫细胞化学方法在人胰岛中检测到它。在胰岛毛细血管的内皮细胞和内分泌细胞中均发现了强烈的P-糖蛋白免疫反应性。在血组织屏障部位的毛细血管以及许多具有分泌/排泄功能的细胞中都发现了P-糖蛋白的强表达。因此，目前的研究结果表明，P-糖蛋白可能在控制细胞外液的成分和内分泌胰岛细胞的细胞内环境方面发挥作用，并可能在调节其分泌活性方面发挥作用。
