Pastan I, Gottesman M M
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Annu Rev Med. 1991;42:277-86. doi: 10.1146/annurev.me.42.020191.001425.
Laboratory investigations indicate that cancer cells can become simultaneously resistant to many different chemotherapeutic drugs that are natural products via the expression of an energy-dependent drug efflux pump. This multidrug transporter is a plasma membrane glycoprotein encoded in the human by the MDR1 gene. Recent clinical studies indicate that expression of the multidrug transporter plays a major role in the intrinsic and acquired resistance to chemotherapy of many human cancers. Strategies aimed at inactivating this drug efflux pump may have significant impact on the treatment of human cancer.
实验室研究表明，癌细胞可通过表达一种能量依赖性药物外排泵，同时对许多不同的天然产物类化疗药物产生耐药性。这种多药转运蛋白是一种质膜糖蛋白，由人类的MDR1基因编码。最近的临床研究表明，多药转运蛋白的表达在许多人类癌症对化疗的固有耐药性和获得性耐药性中起主要作用。旨在使这种药物外排泵失活的策略可能对人类癌症的治疗产生重大影响。
