Saito T, Zhang Z J, Tsuzuki H, Ohtsubo T, Yamada T, Yamamoto T, Saito H
Department of Otolaryngology, Fukui Medical School, Japan.
Brain Res. 1997 Sep 5;767(2):388-92. doi: 10.1016/s0006-8993(97)00821-4.
Expression of P-glycoprotein (P-gp) was detected immunohistochemically in the guinea pig inner ear using mouse anti-P-gp monoclonal antibody C219. P-gp was found only in the capillary endothelial cells of the cochlea and vestibule. The pattern of P-gp immunostaining in the inner ear was similar to that of the brain. The present investigation suggested that P-gp expression in inner ear capillary endothelial cells might play an important role in the blood-inner ear barrier by acting as an extrusion pump.
使用小鼠抗P-糖蛋白单克隆抗体C219，通过免疫组织化学方法检测豚鼠内耳中P-糖蛋白（P-gp）的表达。仅在耳蜗和前庭的毛细血管内皮细胞中发现P-gp。内耳中P-gp免疫染色模式与大脑相似。本研究表明，内耳毛细血管内皮细胞中P-gp的表达可能作为一种外排泵，在血-内耳屏障中起重要作用。
