Poggi A, Donati M B, Polentarutti N, de Gaetano G, Garattini S
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Aug 30;86(3):303-6. doi: 10.1007/BF00286949.
Thrombocytopenia was observed in mice during development and metastatization of Lewis Lung Carcinoma (3LL). Survival of labelled platelets was not modified throughout the observation period, whereas platelet turn-over was markedly reduced, suggesting a defective platelet production. An increase in the splenic platelet pool could be excluded. Other hematological data indicated that, among blood cells, only platelet production was impaired. The origin of thrombocytopenia occurring during spontaneous metastatization of 3LL seems to be quite different from the mechanism of the decrease in platelet count observed after rapid intravenous injection of the same tumoral cells.
在Lewis肺癌（3LL）的发生发展及转移过程中，观察到小鼠出现血小板减少症。在整个观察期内，标记血小板的存活情况未发生改变，而血小板周转率显著降低，提示血小板生成存在缺陷。可排除脾脏血小板池增加的情况。其他血液学数据表明，在血细胞中，只有血小板生成受到损害。3LL自发转移过程中出现的血小板减少症的起源似乎与快速静脉注射相同肿瘤细胞后观察到的血小板计数减少的机制有很大不同。
