Hashimoto T, Araki H, Yoshioka T, Yasui K, Kodama M
Dept. of Surgery, Biwako Ohashi Hospital, Otsu, Japan.
Gan To Kagaku Ryoho. 1992 Dec;19(14):2399-402.
A 77-year-old female with primary duodenal cancer had undergone pancreatoduodenectomy in May, 1989. Postoperative chemotherapy was done in combination with MMC (mitomycin C), lentinan and UFT (combined medicine of tegafur and uracil). In August, 1991, the patient complained of a cough and then was examined for multiple pulmonary metastases from duodenal cancer by chest X-ray and CT-scan. Then, she received 5'-DFUR (400-800 mg) and MMC (total 6 mg). Two months from the start of this therapy, the cough almost vanished and pulmonary lesions were diminished markedly. For about five months, this case corresponded to partial response (PR) according to the response criteria proposed by Koyama-Saitoh. The side effects of 5'-DFUR were diarrhea and anorexia. Therefore, we think that 5'-DFUR and a small dose of MMC yielded a partial response to multiple pulmonary metastases from duodenal cancer.
一名77岁的原发性十二指肠癌女性患者于1989年5月接受了胰十二指肠切除术。术后化疗联合丝裂霉素C（MMC）、香菇多糖和优福定（替加氟与尿嘧啶的复方制剂）进行。1991年8月，患者出现咳嗽，随后通过胸部X线和CT扫描检查发现十二指肠癌多发肺转移。然后，她接受了去氧氟尿苷（5'-DFUR，400 - 800毫克）和MMC（总量6毫克）治疗。从该治疗开始两个月后，咳嗽几乎消失，肺部病变明显缩小。根据小山-斋藤提出的疗效标准，该病例在大约五个月的时间里呈现部分缓解（PR）。5'-DFUR的副作用为腹泻和厌食。因此，我们认为5'-DFUR和小剂量MMC对十二指肠癌多发肺转移产生了部分缓解效果。
