Fujimoto T, Takami M, Okumura Y, Takada T, Kitada M, Tsukahara Y, Shibata T, Murotani M, Iihara K, Watanabe T
Dept. of Surgery, Toyonaka Municipal Hospital.
Gan To Kagaku Ryoho. 1995 Jan;22(1):129-32.
We report a case, showing a complete response to high-dose 5'-DFUR, with pulmonary metastasis from colon cancer. A 52-year-old male patient underwent right hemicolectomy for ascending colon cancer in August, 1991. A recurrence of colon cancer developed in the left lower lung 16 months after surgery, and 5'-DFUR was administered at a dose of 1,600 mg/body/day. The pulmonary metastatic lesion was undetectable on chest X-ray film 9 weeks after the start of this therapy. The dose of 5'-DFUR was then reduced to 600 mg/body/day. Although this condition was maintained for 22 weeks, chest X-ray film again showed the metastatic lesion at the same site in the lung as before. The pulmonary metastasis was resected completely in April, 1994. This is suggested to be an effective therapy for pulmonary metastasis from colon cancer.
我们报告一例结肠癌肺转移患者，其对高剂量5'-去氧氟尿苷治疗呈现完全缓解。一名52岁男性患者于1991年8月因升结肠癌接受了右半结肠切除术。术后16个月左下肺出现结肠癌复发，给予5'-去氧氟尿苷，剂量为1600mg/（人·天）。该治疗开始9周后，胸部X光片上已检测不到肺转移病灶。随后5'-去氧氟尿苷剂量减至600mg/（人·天）。尽管这种情况维持了22周，但胸部X光片再次显示肺部同一部位出现了转移病灶。1994年4月，肺转移灶被完全切除。这表明该疗法对结肠癌肺转移有效。
