Kikkawa N, Tsuchiya Y, Tsumura I, Kobayakawa K, Kawahara T
Department of Surgery, Osaka National Hospital, Japan.
Gan To Kagaku Ryoho. 1991 Oct;18(13):2345-8.
A woman born in 1924 with colon cancer initially operated on approximately four years ago showed a second recurrence in the lung. Concomitant administration of high dose 5'-DFUR plus MMC was started in February, 1990. Chest X-ray examination six weeks after the start of this therapy revealed a remarkable decrease in size of the pulmonary metastatic focus. At 13 weeks after the start of this therapy, the pulmonary metastatic focus showed nearly complete disappearance. The condition above has been maintained until this writing, eight months after the start of this therapy. No recurrence has been observed in the liver and other organs either, while CEA has normalized from 17.6 ng/ml to 0.9 ng/ml. The therapy was discontinued after five courses based on the moderate loss of appetite and complete disappearance of the lung focus. No other side effect than the loss of appetite was detected, and could be safely treated at an outpatient clinic. The above findings suggested that this was an effective and safe therapy for pulmonary metastasis from colon cancers.
一名1924年出生的女性，大约四年前因结肠癌接受了首次手术，现肺部出现第二次复发。1990年2月开始联合使用大剂量5'-去氧氟尿苷（5'-DFUR）和丝裂霉素（MMC）。该治疗开始六周后的胸部X光检查显示，肺转移灶大小显著减小。在该治疗开始13周后，肺转移灶几乎完全消失。直至撰写本文时，即该治疗开始八个月后，上述情况一直保持。肝脏和其他器官也未观察到复发，同时癌胚抗原（CEA）已从17.6 ng/ml恢复正常至0.9 ng/ml。基于中度食欲不振和肺部病灶完全消失，五个疗程后停止治疗。除食欲不振外未检测到其他副作用，且可在门诊安全治疗。上述结果表明，这是一种治疗结肠癌肺转移的有效且安全的疗法。
