BARER G R, NUSSER E
Br J Pharmacol Chemother. 1958 Dec;13(4):372-7. doi: 10.1111/j.1476-5381.1958.tb00223.x.
In cats under chloralose anaesthesia the reflex fall of blood pressure and heart rate caused by injection of veratrine, amidines, diphenhydramine, or ethyl acetoacetate was accompanied by a fall in cardiac output. After veratrine and amidines there was a fall in mean pulmonary arterial pressure and after veratrine no significant change in pulmonary vascular resistance. After diphenhydramine and ethyl acetoacetate there was a rise in mean pulmonary arterial pressure and after diphenhydramine an increase in pulmonary vascular resistance. The effects of veratrine and amidines, but not those of diphenhydramine and ethyl acetoacetate, were abolished by section of the vagi. The main change leading to the fall of cardiac output after amidines was bradycardia.
在水合氯醛麻醉的猫中，注射藜芦碱、脒类、苯海拉明或乙酰乙酸乙酯引起的血压和心率反射性下降伴随着心输出量的降低。注射藜芦碱和脒类后，平均肺动脉压下降，注射藜芦碱后肺血管阻力无显著变化。注射苯海拉明和乙酰乙酸乙酯后，平均肺动脉压升高，注射苯海拉明后肺血管阻力增加。切断迷走神经可消除藜芦碱和脒类的作用，但不能消除苯海拉明和乙酰乙酸乙酯的作用。脒类导致心输出量下降的主要变化是心动过缓。
