Lehmann Heidi S, Blache Dominique, Drynan Eleanor, Tshewang Pema, Blignaut David J C, Musk Gabrielle C
School of Veterinary and Life Sciences, Murdoch University, Perth 6150, Australia.
School of Agriculture and Environment, University of Western Australia, Perth 6009, Australia.
Animals (Basel). 2017 Aug 10;7(8):61. doi: 10.3390/ani7080061.
Juvenile male pigs were sedated for castration. Eight five-month old boars were sedated twice (two weeks apart) with a combination of detomidine (0.1 mg/kg), midazolam (0.2 mg/kg) and either butorphanol (0.2 mg/kg) (Group MDB, n = 8) or morphine (0.2 mg/kg) (Group MDM, n = 8) intramuscularly. The boars were positioned in lateral recumbency and lidocaine (200 mg total) was injected into the testicle and scrotal skin. Castration of a single testicle was performed on two occasions. Sedation and reaction (to positioning and surgery) scores, pulse rate, respiratory rate, haemoglobin oxygen saturation, body temperature, arterial blood gas parameters and the times to immobility and then recovery were recorded. Atipamezole was administered if spontaneous recovery was not evident within 60 min of sedative administration. Data were compared with either a paired-sample -test or a Wilcoxon-Signed Rank Test. There was no difference in sedation score, body temperature, respiratory rate and haemoglobin oxygen saturation between MDB and MDM. Mild hypoxaemia was noted in both groups. There was less reaction to castration after MDB. The pulse rate was higher after MDM sedation. The times to immobility and then recovery were similar. The combination of MDB provided more reliable sedation than MDM. MDB may be useful for sedation for short procedures in pigs, though oxygen supplementation is recommended to avoid hypoxaemia.
幼年雄性猪被麻醉以进行去势手术。八只五个月大的公猪分两次（间隔两周）接受肌肉注射，使用的麻醉组合为右美托咪定（0.1毫克/千克）、咪达唑仑（0.2毫克/千克），以及布托啡诺（0.2毫克/千克）（MDB组，n = 8）或吗啡（0.2毫克/千克）（MDM组，n = 8）。公猪呈侧卧位，将利多卡因（总量200毫克）注射到睾丸和阴囊皮肤中。对单个睾丸进行两次去势手术。记录麻醉和反应（对体位摆放和手术的反应）评分、脉搏率、呼吸频率、血红蛋白氧饱和度、体温、动脉血气参数以及达到不动状态和随后恢复的时间。如果在给予麻醉剂后60分钟内未出现自发恢复，则给予阿替美唑。数据采用配对样本t检验或威尔科克森符号秩检验进行比较。MDB组和MDM组在麻醉评分、体温、呼吸频率和血红蛋白氧饱和度方面没有差异。两组均出现轻度低氧血症。MDB组术后对去势的反应较小。MDM组麻醉后脉搏率较高。达到不动状态和随后恢复的时间相似。与MDM相比，MDB组合提供了更可靠的麻醉效果。MDB可能对猪的短时间手术麻醉有用，不过建议补充氧气以避免低氧血症。
