Ono S, Yamauchi M
Dental Research Center, University of North Carolina, Chapel Hill 27599-7455.
Acta Neurol Scand. 1992 Nov;86(5):481-4. doi: 10.1111/j.1600-0404.1992.tb05128.x.
We measured the levels of amino acids in biopsied skin from eight patients with amyotrophic lateral sclerosis (ALS) and seven controls. The most conspicuous changes in ALS patients were as follows. First, the contents of the acidic amino acids glutamate and aspartate were significantly decreased in ALS, and were negatively and significantly associated with the duration of illness. Second, the levels of the collagen-associated amino acids hydroxyproline, proline, glycine, alanine, and hydroxylysine were significantly decreased in ALS, and correlated inversely with the duration of illness. These results suggest that there are abnormalities of acidic amino acids and collagen-associated amino acids in the skin of patients with ALS. These changes may underlie the pathogenesis of ALS.
我们测量了8例肌萎缩侧索硬化症（ALS）患者和7名对照者活检皮肤中的氨基酸水平。ALS患者最明显的变化如下。首先，ALS患者中酸性氨基酸谷氨酸和天冬氨酸的含量显著降低，且与病程呈负相关且具有显著性。其次，ALS患者中与胶原蛋白相关的氨基酸羟脯氨酸、脯氨酸、甘氨酸、丙氨酸和羟赖氨酸的水平显著降低，且与病程呈负相关。这些结果表明，ALS患者皮肤中存在酸性氨基酸和与胶原蛋白相关的氨基酸异常。这些变化可能是ALS发病机制的基础。
