Ono S, Yamauchi M
Department of Neurology, Teikyo University School of Medicine, Ichihara Hospital, Japan.
J Neurol Neurosurg Psychiatry. 1994 Jan;57(1):94-6. doi: 10.1136/jnnp.57.1.94.
Two cross-links unique to elastin, desmosine and isodesmosine were measured and compared in skin tissue (left upper arm) from 10 patients with amyotrophic lateral sclerosis (ALS) and from seven age-matched controls. The contents of desmosine and isodesmosine were significantly decreased (p < 0.01 and p < 0.01, respectively) in patients with ALS compared with those of controls, and were negatively and significantly associated with duration of illness in ALS patients (r = -0.77, p < 0.01 and r = -0.65, p < 0.05, respectively). The decline in skin desmosine and isodesmosine is more rapid in ALS than in normal ageing. Thus cross-linking of skin elastin is affected in ALS.
在10例肌萎缩侧索硬化症（ALS）患者和7例年龄匹配的对照者的皮肤组织（左上臂）中，对弹性蛋白特有的两种交联物——锁链素和异锁链素进行了测量和比较。与对照组相比，ALS患者的锁链素和异锁链素含量显著降低（分别为p < 0.01和p < 0.01），并且与ALS患者的病程呈负相关且具有显著相关性（分别为r = -0.77，p < 0.01和r = -0.65，p < 0.05）。ALS患者皮肤中锁链素和异锁链素的下降速度比正常衰老更快。因此，ALS会影响皮肤弹性蛋白的交联。
