人细胞色素P450IIE1基因限制性片段长度多态性与肺癌易感性的关联
Association between restriction fragment length polymorphism of the human cytochrome P450IIE1 gene and susceptibility to lung cancer.
作者信息
Uematsu F, Kikuchi H, Motomiya M, Abe T, Sagami I, Ohmachi T, Wakui A, Kanamaru R, Watanabe M
机构信息
Department of Cancer Chemotherapy and Prevention, Tohoku University, Sendai.
出版信息
Jpn J Cancer Res. 1991 Mar;82(3):254-6. doi: 10.1111/j.1349-7006.1991.tb01838.x.
Abstract
Cytochrome P450IIE1 (P450IIE1) is involved in metabolic activation of carcinogenic nitrosamines, aniline and benzene. We detected a restriction fragment length polymorphism of the human P450IIE1 gene with the restriction endonuclease DraI. The population was thus divided into three genotypes, namely, heterozygotes (CD) and two forms of homozygotes (CC and DD). The distribution of these genotypes among lung cancer patients differed from that among controls with statistical significance of P less than 0.05 (chi 2 = 7.01 with 2 degrees of freedom). This result strongly suggests that host susceptibility to lung cancer is associated with the DraI polymorphism of the P450IIE1 gene.
摘要
细胞色素P450IIE1（P450IIE1）参与致癌亚硝胺、苯胺和苯的代谢活化。我们用限制性内切酶DraI检测了人类P450IIE1基因的限制性片段长度多态性。人群因此被分为三种基因型，即杂合子（CD）和两种纯合子形式（CC和DD）。这些基因型在肺癌患者中的分布与对照组不同，P值小于0.05，具有统计学意义（自由度为2时，卡方值 = 7.01）。这一结果强烈表明，宿主对肺癌的易感性与P450IIE1基因的DraI多态性有关。
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