Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S
Eisei Shikenjo Hokoku. 1991(109):151-3.
The raw material of epitiostanol was examined for preparation of "Epitiostanol Reference Standard". Analytical results for the sample were as follows: melting point 130.7 degrees C (decomposition); UV spectrum indicates absorption maximum at 263 nm in ethanol; IR spectrum indicates specific absorption at 2920, 1383, 1056 and 590 cm-1; optical rotation [alpha]20D+ 24.4 degrees; no impurity was found by TLC, but a small amount of one was found by HPLC analysis and the purity is assumed to be 99.5%; water content 1.52%. Based on the results, the present raw material was authorized to be the Reference Standard of the National Institute of Hygienic Sciences.
对用于制备“依替膦酸二钠对照品”的依替膦酸二钠原料进行了检验。样品的分析结果如下：熔点130.7℃（分解）；紫外光谱表明在乙醇中263nm处有最大吸收；红外光谱表明在2920、1383、1056和590cm-1处有特定吸收；旋光度[α]20D + 24.4°；薄层色谱法未发现杂质，但高效液相色谱分析发现有少量杂质，纯度假定为99.5%；水分含量1.52%。基于这些结果，本原料被批准为国立卫生科学研究所的对照品。
