Popov T, Mikhaĭlova A
Probl Khig. 1992;17:146-51.
The carbon sulfide effect on the oxidase mixed function activity (OMF) is studied in 172 workers from plant producing artificial silk, distributed in 5 groups, according to index of exposure, defining the strength and duration of the toxic effect. The OMF activity is evaluated by giving aminopyrine and determining its metabolites in urine. The exposure to carbon sulfide effects the OMF activity. It is expressed by inhibition of OMF, manifested most frequently in quality controllers and transporters (31%) and heads of shift and section foremen (25%). In the remaining groups the OMF inhibition, estimated after the first aminopyrine metabolite, varies from 16% to 21%. Even more significant are the changes in the excretion of the second metabolite, where the deviation of the referent values reaches 56% for IInd group, 55% in IIIrd group and 45% in Ist group.
对一家生产人造丝工厂的172名工人进行了研究，根据接触指数将他们分为5组，以确定硫化碳对氧化酶混合功能活性（OMF）的影响，该指数定义了毒性作用的强度和持续时间。通过给予氨基比林并测定其尿液中的代谢产物来评估OMF活性。接触硫化碳会影响OMF活性。这表现为OMF受到抑制，在质量控制人员和运输人员中最为常见（31%），在轮班主管和工段长中也较为常见（25%）。在其余组中，根据第一种氨基比林代谢产物估计，OMF抑制率在16%至21%之间。第二种代谢产物排泄量的变化更为显著，第二组参考值偏差达到56%，第三组为55%，第一组为45%。
