Popov T
Probl Khig. 1983;8:64-73.
The significance of the mixed function oxidases (MFO) for hygienic toxicology is determined by the exceptional role of that enzyme system in the biotransformation of xenobiotics. On the other hand, the changes in MFO activity are some of the basic mechanisms in organism adaptation to repeated toxic exposures. An original method is elaborated for the assessment of MFO activity, used in the examinations of workers, exposed to carbon sulphide, polycyclic aromatic hydrocarbons, organic solvents, vinylchloride and styrene. Representative groups from the population, that live in a region with strongly polluted atmospheric air were studied. The results obtained reveal that the alterations in MFO activity are an early manifestation of compensatory strain of adaptive mechanisms of organisms and could be used in the diagnosis of premorbid states with chemical etiology, in checking the conformity of MAC in force, for the purposes of vocational selection, etc. The method is easy to perform and could be used for the purposes of therapeutic-diagnostic activity in some other medical specialties: gastroenterology, infectious diseases, etc.
混合功能氧化酶（MFO）对卫生毒理学的意义取决于该酶系统在异源物质生物转化中的特殊作用。另一方面，MFO活性的变化是生物体适应反复接触毒物的一些基本机制。本文阐述了一种用于评估MFO活性的原始方法，该方法用于对接触二硫化碳、多环芳烃、有机溶剂、氯乙烯和苯乙烯的工人进行检查。对生活在大气污染严重地区的具有代表性的人群进行了研究。所得结果表明，MFO活性的改变是生物体适应机制代偿性应激的早期表现，可用于化学病因学的病前状态诊断、检查现行最高容许浓度的符合性、职业选择等目的。该方法操作简便，可用于其他一些医学专科（如胃肠病学、传染病学等）的治疗诊断活动。
