Loh C-H, Shih T-S, Liou S-H, Lin Y-C, Hsieh A-T, Chen C-Y, Liao G-D
Department of Family Medicine & Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, 325 Cheng-Kung Road, Sec. 2, Nei-Hu, Taipei, Taiwan 114, ROC.
Occup Environ Med. 2003 Sep;60(9):E7. doi: 10.1136/oem.60.9.e7.
2-Ethoxy ethyl acetate (2-EEA) is a solvent with broad industrial and commercial applications. It has been reported to cause hematological toxicity, infertility, and teratogenesis.
To investigate the haematological effects in 2-EEA exposed workers.
Workers from one silk screening shop (n = 29), using 2-EEA as the major cleaning and printing solvent, were recruited as a high exposure group. Workers with indirect and non-exposure to 2-EEA (n = 56) were recruited as the comparison group. Venous blood was collected for blood routine examination. Air concentration of 2-EEA in this plant was measured by eight hour personal sampling.
The geometric mean (GM) of air concentration of 2-EEA in the high exposure group was 7.41 ppm (range 1.35-16.5 pppm). The mean exposure of female workers (GM = 9.34 ppm) was significantly higher than that of male workers (GM = 4.87 ppm). The GM of air 2-EEA concentration in the comparison group was 0.07 ppm (range: non-detectable to 3.62 ppm, n = 26). The haemoglobin and haematocrit in the female high 2-EEA exposure workers were significantly lower than those of female workers in the comparison group. No difference was found between male 2-EEA high exposure and comparison group workers. The haemoglobin, haematocrit, and RBC count in the study population had a significant dose-response relation with air 2-EEA levels.
Results suggest that 2-EEA is a haematological toxicant, which leads to anaemic status in high exposure female workers.
2-乙氧基乙酸乙酯（2-EEA）是一种具有广泛工业和商业应用的溶剂。据报道，它会导致血液毒性、不育和致畸作用。
研究2-EEA暴露工人的血液学影响。
招募一家丝网印刷店的工人（n = 29）作为高暴露组，该店使用2-EEA作为主要的清洁和印刷溶剂。招募间接或未接触2-EEA的工人（n = 56）作为对照组。采集静脉血进行血常规检查。通过八小时个人采样测量该工厂空气中2-EEA的浓度。
高暴露组空气中2-EEA浓度的几何平均值（GM）为7.41 ppm（范围为1.35 - 16.5 ppm）。女工的平均暴露量（GM = 9.34 ppm）显著高于男工（GM = 4.87 ppm）。对照组空气中2-EEA浓度的GM为0.07 ppm（范围：未检出至3.62 ppm，n = 26）。2-EEA高暴露女工的血红蛋白和血细胞比容显著低于对照组女工。2-EEA高暴露男工与对照组男工之间未发现差异。研究人群中的血红蛋白、血细胞比容和红细胞计数与空气中2-EEA水平存在显著的剂量反应关系。
结果表明，2-EEA是一种血液学毒物，可导致高暴露女工出现贫血状态。
