Friedman G D, Gerard M J, Ury H K
JAMA. 1976 Nov 29;236(22):2498-500.
Of 298 outpatients receiving clindamycin for a variety of indications, diarrhea developed in ten (3.4%); none were diagnosed as having pseudo-membranous colitis. This is well within the range of relative frequencies of diarrhea development (0% to 22.2%) reported in 45 previous studies. Reliance solely on computer-recorded instances of diarrhea yielded a substantial underestimate of diarrhea occurence, but the rate was still significantly higher (P less than .05) in clindamycin users than in nonusers.
在298名因各种适应症接受克林霉素治疗的门诊患者中，有10人（3.4%）出现腹泻；无人被诊断为伪膜性结肠炎。这完全在之前45项研究报告的腹泻发生率相对频率范围（0%至22.2%）之内。仅依靠计算机记录的腹泻病例会大幅低估腹泻发生率，但克林霉素使用者的腹泻发生率仍显著高于未使用者（P小于0.05）。
