Yamanishi K
Department of Virology, Osaka University, Japan.
Infect Agents Dis. 1992 Jun;1(3):149-55.
The newly isolated virus, human herpesvirus 6 (HHV-6), causes exanthem subitum (or roseola infantum) as the primary infection. Liver dysfunction and neurological disorders are observed during exanthem subitum. Seroepidemiological studies have shown that almost all children are infected with HHV-6 about 6-24 months after birth. This virus also causes other diseases including lymphadenitis and infectious mononucleosis-like disease. HHV-6 has cellular tropism for CD4+ lymphocytes, in which it replicates in vivo. Its transmission is probably airborne early in life, mainly from mother to child, because it is often secreted in the saliva of healthy adults having antibody to HHV-6. Latent infection follows the primary infection and the virus can often be reactivated under conditions of immunosuppression such as AIDS or organ transplantations. The site of its latent infection is not yet known, but could be monocytes/macrophages.
新分离出的病毒——人类疱疹病毒6型（HHV - 6），在初次感染时会引发幼儿急疹（或婴儿玫瑰疹）。在幼儿急疹期间可观察到肝功能障碍和神经紊乱。血清流行病学研究表明，几乎所有儿童在出生后6 - 24个月会感染HHV - 6。这种病毒还会引发其他疾病，包括淋巴结炎和传染性单核细胞增多症样疾病。HHV - 6对CD4 +淋巴细胞具有细胞嗜性，它在体内可在这些细胞中复制。其传播在生命早期可能通过空气传播，主要是母婴传播，因为它常存在于具有HHV - 6抗体的健康成年人的唾液中。初次感染后会出现潜伏感染，并且该病毒在免疫抑制条件下（如艾滋病或器官移植）常常会重新激活。其潜伏感染的部位尚不清楚，但可能是单核细胞/巨噬细胞。
