Lapis P, Freeman J, Bitter M A, Golitz L E
Department of Pathology and Dermatology, University of Colorado Health Sciences Center, Denver.
Acta Morphol Hung. 1992;40(1-4):249-55.
Recently, the presence of deleted forms of the HTLV-I provirus was described in 6 out of 6 cases of CTCL. We investigated whether the presence of these viral genomes could be verified in 20 patients with CTCL using the polymerase chain reaction (PCR) and Southern blot analysis. Only one of the 20 cases showed a band corresponding to the pX region of HTLV-I. These data indicate that in the majority of CTCL cases, sequences closely related to HTLV-I are not present, or their copy number is below the limit of detection employed in this study.
最近，在6例蕈样肉芽肿病例中均发现了人嗜T淋巴细胞病毒I型（HTLV-I）前病毒的缺失形式。我们使用聚合酶链反应（PCR）和Southern印迹分析，研究了这20例蕈样肉芽肿患者中是否能检测到这些病毒基因组。20例病例中只有1例显示出与HTLV-I的pX区域相对应的条带。这些数据表明，在大多数蕈样肉芽肿病例中，不存在与HTLV-I密切相关的序列，或者其拷贝数低于本研究采用的检测限。
