Asin K E, Davis J D, Bednarz L
Abbott Laboratories, Neuroscience Research Division, Abbott Park, IL 60064.
Psychopharmacology (Berl). 1992;109(4):415-21. doi: 10.1007/BF02247717.
The serotonergic agonists fenfluramine and fluoxetine and the catecholaminergic agonists amphetamine and phenylpropanolamine are well known to cause a reduction in intake in rats. In the studies reported here we investigated the effects of these drugs on the microstructure of licking behavior of the rat ingesting 0.4 M sucrose. The purpose was to examine the similarities in the behavioral effects within and between these two classes of anorectic agents. The serotonergic agonists fenfluramine and fluoxetine caused a reduction in intake primarily by reducing the size of bursts and clusters of licking within the test meal without affecting the duration of the meal, suggesting a reduction in the palatability of the test solution. The catecholamine agonists amphetamine and phenylpropanolamine reduced intake primarily by reducing the number of bursts and clusters without affecting their size, suggesting a fractionation in the organization of the normal pattern of ingestion. The differences between the two serotonin and the two catecholamine agonists on the microstructure of the licking behavior suggest a different effect of the two neurotransmitters on the motor system that controls ingestive behavior. The similarities between the two different agonists within each class suggests a common neurotransmitter mechanism responsible for these two different effects on the behavior of the animals.
血清素能激动剂芬氟拉明和氟西汀以及儿茶酚胺能激动剂苯丙胺和苯丙醇胺可使大鼠摄入量减少，这是众所周知的。在本文报道的研究中，我们研究了这些药物对摄入0.4M蔗糖的大鼠舔舐行为微观结构的影响。目的是检验这两类厌食剂在行为效应上的异同。血清素能激动剂芬氟拉明和氟西汀主要通过减少测试餐中舔舐的爆发和群组大小来减少摄入量，而不影响餐的持续时间，这表明测试溶液的适口性降低。儿茶酚胺激动剂苯丙胺和苯丙醇胺主要通过减少爆发和群组数量来减少摄入量，而不影响其大小，这表明正常摄入模式的组织出现了部分紊乱。两种血清素激动剂和两种儿茶酚胺激动剂在舔舐行为微观结构上的差异表明，这两种神经递质对控制摄食行为的运动系统有不同的影响。每类中两种不同激动剂之间的相似性表明，存在一种共同的神经递质机制导致对动物行为产生这两种不同的影响。
