Deijen J B, van der Beek E J, Orlebeke J F, van den Berg H
Department of Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Psychopharmacology (Berl). 1992;109(4):489-96. doi: 10.1007/BF02247729.
This study evaluates the effects of vitamin B-6 supplementation (20 mg pyridoxine HCL daily for 3 months) on mood and performance in 38 self-supporting healthy men, aged between 70-79 years. Effects were compared with 38 controls who received placebo and were matched for age, plasma pyridoxal-5'-phosphate (PLP) concentration and intelligence score. Before and after drug intervention vitamin B-6 status was determined, and mood and performance were measured by means of a computerized testing system. In addition, the phasic pupil response was measured in order to assess mental effort. Positive effects of vitamin B-6 supplementation were only found with respect to memory, especially concerning long-term memory. In view of the finding that mental performance improvement and delta PLP values were most strongly correlated within an intermediate range of delta PLP, it is suggested that cognitive effects are primarily associated with a certain range of vitamin B-6 status increment. The general conclusion is that vitamin B-6 supplementation improves storage of information modestly but significantly.
本研究评估了补充维生素B-6（每日20毫克盐酸吡哆醇，持续3个月）对38名70至79岁自立健康男性的情绪和表现的影响。将其效果与38名接受安慰剂的对照组进行比较，对照组在年龄、血浆磷酸吡哆醛（PLP）浓度和智力得分方面进行了匹配。在药物干预前后测定维生素B-6状态，并通过计算机测试系统测量情绪和表现。此外，测量了阶段性瞳孔反应以评估脑力劳动。补充维生素B-6的积极效果仅在记忆力方面发现，尤其是长期记忆。鉴于在PLP变化的中间范围内，心理表现改善与PLP变化值之间的相关性最强，表明认知效果主要与一定范围的维生素B-6状态增加有关。总的结论是，补充维生素B-6适度但显著地改善了信息存储。
