Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, PO Box 1416643931, Tehran, Iran.
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Public Health Nutr. 2021 May;24(7):1787-1797. doi: 10.1017/S1368980020002943. Epub 2020 Sep 16.
B-vitamins affect brain function through multiple pathways. Given limited evidence on the relationship between dietary intake of these vitamins and psychological disorders, we examined dietary intake of vitamin B6-9-12 in relation to psychological disorders among Iranian women.
Cross-sectional study. Dietary intake was assessed using a valid and reliable FFQ. To assess psychological disorders, we used a version of the Depression Anxiety Stress Scale-21 validated in Iran.
Ten public health centres in southern Tehran, Iran.
A total of 447 female participants aged 20-50 years.
The median values of vitamin B6 (pyridoxine), B9 (folate) and B12 (cobalamin) were 1·30 mg/d, 313·89 µg/d and 3·99 µg/d, respectively. After adjustment for potential confounders, dietary vitamin B6 intake was associated with lower odds of depression (OR: 0·54; 95 % CI: 0·31, 0·95; Ptrend: 0·03). However, there was a positive association between dietary vitamin B12 intake with the odds of depression (OR: 2·05; 95 % CI: 1·17, 3·60; Ptrend: 0·01) and psychological distress (OR: 2·00; 95 % CI: 1·17, 3·41; Ptrend: 0·01). No association was found between vitamin B9 with any psychological disorders.
Women with higher dietary intakes of vitamin B6 had lower likelihood of depression. However, women with higher dietary intake of vitamin B12 had higher odds of depression and psychological distress. Future prospective studies in different populations are needed to clarify whether B-vitamin deficiency is a cause or consequence of psychological disorders.
B 族维生素通过多种途径影响大脑功能。鉴于关于这些维生素的饮食摄入与心理障碍之间关系的有限证据，我们研究了伊朗女性维生素 B6-9-12 的饮食摄入与心理障碍之间的关系。
横断面研究。饮食摄入使用经过验证的可靠 FFQ 进行评估。为了评估心理障碍，我们使用了在伊朗经过验证的抑郁焦虑压力量表-21 的一个版本。
伊朗德黑兰南部的 10 个公共卫生中心。
共 447 名年龄在 20-50 岁之间的女性参与者。
维生素 B6（吡哆醇）、B9（叶酸）和 B12（钴胺素）的中位数分别为 1·30mg/d、313·89μg/d 和 3·99μg/d。调整潜在混杂因素后，饮食维生素 B6 摄入与抑郁的几率较低相关（OR：0·54；95%CI：0·31，0·95；Ptrend：0·03）。然而，饮食维生素 B12 摄入与抑郁的几率呈正相关（OR：2·05；95%CI：1·17，3·60；Ptrend：0·01）和心理困扰（OR：2·00；95%CI：1·17，3·41；Ptrend：0·01）。维生素 B9 与任何心理障碍均无关联。
饮食中维生素 B6 摄入量较高的女性患抑郁症的可能性较低。然而，饮食中维生素 B12 摄入量较高的女性患抑郁症和心理困扰的几率较高。需要在不同人群中进行未来的前瞻性研究，以明确 B 族维生素缺乏是心理障碍的原因还是后果。
