CP - 82,996，一种与莫能菌素相关的新型双糖苷聚醚抗生素，由马杜拉放线菌产生。

CP-82,996, a novel diglycoside polyether antibiotic related to monensin and produced by Actinomadura sp.

作者信息

Dirlam J P, Belton A M, Bordner J, Cullen W P, Huang L H, Kojima Y, Maeda H, Nishiyama S, Oscarson J R, Ricketts A P

机构信息

Central Research, Pfizer Inc., Groton, CT 06340.

出版信息

J Ind Microbiol. 1990 Oct;6(2):135-42. doi: 10.1007/BF01576433.

DOI:10.1007/BF01576433

PMID:1366920

Abstract

A new polyether antibiotic CP-82,996 (C50H86O16) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53764). Following purification by silica gel column chromatography and crystallization, the structure of CP-82,996 was determined by a single crystal X-ray analysis. The structure is closely related to monensin, but is unique in that it contains two sugar groups, whereas monensin has none. The 1H and 13C NMR chemical shifts and assignments for CP-82,996 were elucidated, and they were compared with those determined previously for monensin. CP-82,996 is active against certain Gram-positive bacteria, and is a very potent anticoccidial agent. It effectively controlled chicken coccidiosis caused by several Eimeria species at 5-10 ppm in feed, and is 10-20 times more potent than monensin.

摘要

一种新的聚醚抗生素CP - 82,996（C50H86O16）通过溶剂萃取法从马杜拉放线菌（ATCC 53764）的发酵液中分离得到。经硅胶柱色谱纯化和结晶后，通过单晶X射线分析确定了CP - 82,996的结构。该结构与莫能菌素密切相关，但独特之处在于它含有两个糖基，而莫能菌素没有。阐明了CP - 82,996的1H和13C NMR化学位移及归属，并与先前测定的莫能菌素的相关数据进行了比较。CP - 82,996对某些革兰氏阳性菌有活性，是一种非常有效的抗球虫剂。它在饲料中以5 - 10 ppm的浓度能有效控制由几种艾美耳球虫引起的鸡球虫病，效力比莫能菌素强10 - 20倍。