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Simaomicin (LL-D42067), a novel antibiotic from Actinomadura madurae. I. Taxonomy, fermentation and biological activity.

作者信息

Maiese W M, Korshalla J, Goodman J, Torrey M J, Kantor S, Labeda D P, Greenstein M

机构信息

Medical Research Division, American Cyanamid Company, Lederle Laboratories, Pearl River, New York 10965.

出版信息

J Antibiot (Tokyo). 1990 Sep;43(9):1059-63. doi: 10.7164/antibiotics.43.1059.

DOI:10.7164/antibiotics.43.1059
PMID:2211367
Abstract

A new antibacterial antibiotic, designated simaomicin alpha (LL-D42067 alpha) was isolated from the fermentation broth of an actinomycete strain. Based on cultural, physiological, morphological and chemical characteristics, culture LL-D42067 was identified as a new subspecies of Actinomadura madurae. Simaomicin alpha demonstrated potent activity against Gram-positive bacteria and was active in vivo against a variety of Eimeria species causing coccidiosis in chickens.

摘要

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