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通过定向发酵和补料发酵生产去铁胺E及新类似物。

Production of desferrioxamine E and new analogues by directed fermentation and feeding fermentation.

作者信息

Meiwes J, Fiedler H P, Zähner H, Konetschny-Rapp S, Jung G

机构信息

Lehrbereich Mikrobiologie/Antibiotika, Universität Tübingen, Federal Republic of Germany.

出版信息

Appl Microbiol Biotechnol. 1990 Feb;32(5):505-10. doi: 10.1007/BF00173718.

DOI:10.1007/BF00173718
PMID:1367428
Abstract

Streptomyces olivaceus TU 2718 produces the siderophore desferrioxamine E. Production depends on L-lysine and iron concentrations in the medium. With optimized conditions the yield of desferrioxamine E could be increased to 12 g/l in feeding fermentations. Supplementation of the basic production medium with natural and synthetic precursors of desferrioxamine E led to the production of twelve new analogues of desferrioxamine E.

摘要

橄榄色链霉菌TU 2718可产生铁载体去铁胺E。其产量取决于培养基中L-赖氨酸和铁的浓度。在优化条件下，补料发酵中去铁胺E的产量可提高至12 g/l。在基础生产培养基中添加去铁胺E的天然和合成前体，可产生12种新的去铁胺E类似物。

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本文引用的文献

1
The biosynthesis of hadacidin.杀念珠菌素的生物合成
Biochemistry. 1966 Jan;5(1):74-81. doi: 10.1021/bi00865a011.
2
[Metabolic products of microorganisms. 65. Ferrioxamine from Eubacteriales].[微生物的代谢产物。65. 来自真细菌目的铁载体]
Arch Mikrobiol. 1968;62(3):257-63.
3
Separation of amino acids and antibiotics by narrow-bore and normal-bore high-performance liquid chromatography with pre-column derivatization.
J Chromatogr. 1987 Jan 16;386:229-41. doi: 10.1016/s0021-9673(01)94600-x.
代谢多功能耐寒南极细菌假单胞菌 ANT_H12B 是一种高效产生铁载体和伴随代谢物 (SAM) 的细菌，这些物质对农业具有重要用途。
Microb Cell Fact. 2023 Apr 29;22(1):85. doi: 10.1186/s12934-023-02105-2.
4
Perspective on the biotechnological production of bacterial siderophores and their use.关于细菌 siderophores 的生物技术生产及其应用的观点。
Appl Microbiol Biotechnol. 2022 Jun;106(11):3985-4004. doi: 10.1007/s00253-022-11995-y. Epub 2022 Jun 8.
5
Cyclic Analogs of Desferrioxamine E Siderophore for Ga Nuclear Imaging: Coordination Chemistry and Biological Activity in .去铁胺 E 类环状小分子铁载体用于镓核医学成像：配位化学和生物学活性研究
Inorg Chem. 2021 Dec 6;60(23):17846-17857. doi: 10.1021/acs.inorgchem.1c02453. Epub 2021 Nov 16.
6
Signalling and Bioactive Metabolites from sp. RK44.RK44 菌产生的信号分子和生物活性代谢产物。
Molecules. 2020 Jan 22;25(3):460. doi: 10.3390/molecules25030460.
7
Discovery of nicoyamycin A, an inhibitor of uropathogenic Escherichia coli growth in low iron environments.烟霉素A的发现，一种在低铁环境中抑制尿路致病性大肠杆菌生长的抑制剂。
Chem Commun (Camb). 2017 Nov 28;53(95):12778-12781. doi: 10.1039/c7cc07732g.
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9
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Appl Environ Microbiol. 2015 May 1;81(9):3132-41. doi: 10.1128/AEM.03520-14. Epub 2015 Feb 27.
10
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World J Microbiol Biotechnol. 2014 Jan;30(1):331-4. doi: 10.1007/s11274-013-1425-y. Epub 2013 Jul 10.
4
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Biol Met. 1988;1(1):51-6. doi: 10.1007/BF01128017.
5
Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. II. Physico-chemical properties and structure determination.
J Antibiot (Tokyo). 1987 Dec;40(12):1671-6. doi: 10.7164/antibiotics.40.1671.
6
Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. I. Taxonomy of the producing organism, isolation and biological properties.
J Antibiot (Tokyo). 1987 Dec;40(12):1664-70. doi: 10.7164/antibiotics.40.1664.
7
Cloning and expression of two genes of Streptomyces pilosus involved in the biosynthesis of the siderophore desferrioxamine B.
Gene. 1988 Apr 29;64(2):179-88. doi: 10.1016/0378-1119(88)90333-2.
8
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Biol Met. 1989;2(1):1-5. doi: 10.1007/BF01116193.
9
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Arch Microbiol. 1977 Dec 15;115(3):323-31. doi: 10.1007/BF00446459.